Chemotherapy and radiation were proven risk factors for the development of second malignancies among cancer survivors. Traditionally, radiation exposure is considered as one of the most important risk factor for cancer development. Radiation and chemotherapy treatments have a crucial role in the treatment of early cervical cancer, decreasing the risk of cancer recurrence and improving survival, but such treatments are also associated to an increased risk of second malignancies after exposure, especially, in long-term smokers . However, no significant high-standardized incidence ratios were observed among the radiation group in a large population-based study using SEER data. The authors explained that a half of the patients were none/unknown status of radiotherapy which could explained such results. In our population-based study using SEER data, significant high incidence ratios were observed in both radiation group and chemotherapy group. With the improvement of radiotherapy technology, the application of Intensity-modulated radiation therapy (IMRT) and dimensional conformal radiation therapy (3D-CRT) has become more and more common. Our data cannot assess whether IMRT and 3D-CRT will increase the risk of second primary tumor. No significant SIR was detected in Surgical treatment group.